We study Gene Regulatory Networks, the “wiring diagrams” describing which genes become turned on and which are turned off in any given cell. The function of a cell, its fate or identity, is driven by the combination of genes that are expressed.
Thus, Gene Regulatory Networks show us how cells acquire their particular identity (as in a developing embryo), or change their identity (as during the process of regeneration following an injury), or lose their identity altogether (as in cancer).
See more on the Research page
- August 22, 2013: “Employing BAC-reporter constructs in the sea anemone Nematostella vectensis” published in Integrative and Comparative Biology:
- June 5, 2013: “A quantitative reference transciptome for Nematostella vectensis early embryonic development: a pipeline for de novo assembly in emerging model systems,” just published in Evodevo: http://www.ncbi.nlm.nih.gov/pubmed/23731568
- April 11, 2013: “Notch and Nodal control forkhead factor expression in the specification of multipotent progenitors in sea urchin” just published in Development: http://www.ncbi.nlm.nih.gov/pubmed/23533178